The Powerful List of Dairy Ingredients

The Powerful List of Dairy Ingredients

Milk Protein & Bioactive

Lactoferrin

Product Definition

Bovine Lactoferrin is a biologically active milk protein isolated from fresh cow’s milk or fresh whey.

Colostral Lactoferrin is a biologically active milk protein isolated from fresh colostrum.

Composition

Other Characteristics

Product Labeling

Recommended identifications:   Lactoferrin (for lactoferrin derived from fresh milk or fresh whey)

Colostral Lactoferrin (for lactoferrin derived from fresh colostrum)

Protein Quality

Protein Digestibility Corrected Amino Acid Score (PDCAAS)..close to 1.00
Digestible Indispensable Amino Acid Score (DIAAS)................................1.0

Functionality and Applications

HIgh Performance:
Antioxidant properties
Antimicrobial properties
Medium Performance:
Water Binding
Emulsification
Foaming

Lactoferrin has multiple functions, including immune regulation, anti-inflammation, antibacterial, antiviral, and antioxidant activity.  It is non-toxic and has good compatibility with supplements, so it has been used widely in food nutrition, drug carriers, biotechnology and feed development applications (1).

(1) Cao, X, Y Ren, Q Lu, K Wang, Y Wu, Y Wang, Y Zhang, X-S Cui, Z Yang, Z Chen.  Lactoferrin: A glycoprotein that plays an active role in human health. Frontiers in Nutrition. 9. doi: 10.3389/fnut.2022.1018336

Lactoferrin is of interest in infant nutrition because of its roles in supporting gastrointestinal development and boosting the immune system. It is typically used in foods, beverages, supplements, infant nutrition, immune support, and cosmetics.

Because it supports the immune system, helps maintain iron homeostasis, and has anti-inflammatory properties, bovine Lf is also of value in adult nutrition (1). Bovine Lf and its peptides exert beneficial effects on inflammation and neoplastic cell proliferation in colorectal cancer, participating directly in carcinogenesis or in the modulation of the immune response to this cellular process (2). Furthermore, Bovine Lf can be used as a biomarker and a noninvasive diagnostic supporting test in patients with inflammatory disease or infectious bowel disease (2).

Colostral Lactoferrin is typically used in dietary supplements and animal nutrition.

The antioxidant activity of LF can be attributed to the presence of sulfhydryl groups in its amino acid structure, including Met and Cys, which can act as antioxidants through reduction reactions (3).

Product Examples

Credit: Innova Market Insights

ByHeart Whole Nutrition Infant Formula

Purality Health Probiotic Dietary Supplement

Sesderma Lactyferrin Hand Sanitizer

Vita Bubs Lactoferrin for Baby Dietary Supplement

References:

(1) Kim, B J, R F Kuhfeld, J L Haas, Y M Anaya, R R Martinez, B N P Sah, B Breen, K Newsham, C A Malinczak, D C Dallas. 2024. Human and bovine lactoferrin: Comparing the retained intact protein and peptide release. 16(14): DOI10.3390/nu16142360

(2) Ramirez-Rico, G, M E Drago-Serrano, N Leon-Sicairos, M de la Garza. 2022. Lactoferrin: A nutraceutical with activity against colorectal cancer. Frontiers in Pharmacology. doi: 10.3389/fphar.2022.855852

(3) Wang, C., Y Lu, B Xia, X Li, X Huan, C Dong. 2024. Complexation of bovine lactoferrin with selected phenolic acids via noncovalent interactions: Binding mechanisms and altered functionality. J Dairy Sci. 107(7) 4189-4204.

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